From 90E:
(Airport) This puts you onto the expressway 33E. Follow all the way to the end. 33E will run off onto Genesee St. Proceed 1 mile down Genesee. The Holiday Inn will be on your left side.

From 90W:
Exit 49 (Depew) Go through toll and make a right onto Transit Rd. (Rt. 78). Proceed 1 mile to Genesee St. Rt. 33 and make a right. The Holiday Inn is on the right approximately 1 mile.

From Peace Bridge Canada:
Go through toll barrier and take I-190S approximately 7 miles to exit 90E. Exit 51E (Airport). This puts you onto expressway 33E. Follow all the way to the end. 33E will run off onto Genesee St. Proceed 1 mile down Genesee. The Holiday Inn will be on your left side.

From Lewiston/Queenston Bridge Niagara Falls:
take 190S approximately 13 miles to exit N16, take Rt. 290E approximately 10 miles to 90W to exit 51E (Airport Rt. 33). Follow Rt. 33 all the way to the end. Rt. 33 runs off onto Genesee St. Holiday Inn will be 1 mile on your left

From East/West Airport Terminal:
Exit Airport and take left onto Genesee St. Holiday Inn will be on the left side of Genesee St. approximately ¼ mile.